CANCELLED: Seminar - Konstantin Salnikow

photo of Dr. Konstantin Salnikow
February 24, 2020 - 12:00pm
Location: 
601 Fairchild

Program Director

Divison of Cancer Biology

National Cancer Institute

Host: Brent Stockwell

Title: Iron and Cancer

Iron can accept or donate electrons and as the result iron exhibits high redox activity. The reactive properties make iron a key player in diverse biological reactions including energy metabolism, respiration, and DNA synthesis and repair. Due to the poor iron bioavailability, organisms have developed very efficient mechanisms for iron absorption and conservation. As there is no excretory mechanism for iron it is accumulated in the body during the lifetime. Epidemiological studies have demonstrated an association between excess body iron levels and increased cancer incidence and risk and experimental studies have implicated excess iron in cancer initiation, tumor growth, and metastasis. It now well established that cancer cells exhibit an iron-seeking phenotype which is exemplified by the dysregulation of iron metabolic proteins and elevated oxidative stress. Iron accumulation in cancer cells select them for resistance to different forms of cell death, including ferroptosis. Uniquely, both iron excess and iron depletion can be utilized in anticancer therapies. Investigation of iron metabolism in cancer is actively growing NCI portfolio.

 

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