Hybrid Seminar - Kassie Ori-McKenney
September 27, 2021 - 12:00pm
601 Fairchild or Join Over Zoom
Department of Molecular and Cellular Biology
Title: Microtubule Cartography: The Role of Microtubule-Associated Proteins in Defining the Cellular Landscape
Abstract: Cellular function is intimately linked to cellular architecture, which is largely governed by cytoskeletal networks. It is therefore essential to understand the regulatory mechanisms of cytoskeleton organization as a cell develops, changes, or maintains its internal structure, because altering these processes can disrupt cell function and ultimately lead to cellular pathology. Our lab studies the microtubule cytoskeleton and the microtubule-associated proteins (MAPs) that regulate a myriad of network activities. Using in vitro reconstitution of purified proteins, we have found that these MAPs exhibit diverse binding behaviors on the microtubule lattice and differentially affect microtubule motors, highlighting an essential role for MAPs in gating access to the lattice. We are now studying the biochemical and genetic relationships between kinases, MAPs, and motors both in vitro and in vivo using Drosophila melanogaster as a model system. We aspire to construct a comprehensive network to elucidate the multiple ways in which disease-relevant proteins modulate the microtubule cytoskeleton during different cellular processes.
Hybrid seminar. Limited in-person attendance in room 601 Fairchild. Others are encouraged to join over Zoom. Please email [email protected] for a Zoom link for this seminar.
Department of Biological Sciences
500 Fairchild Center
Mail Code 2401
1212 Amsterdam Avenue
New York, NY 10027