Rachford and Carlota A. Harris Professor
Department of Pathology
Stanford University School of Medicine
Host: Jellert Gaublomme
Title: Pathology from the subcellular scale on up
Abstract: I will present evidence of deep internal order in immune functionality demonstrating that differentiation and immune activities have evolved with a definable “shape”. Further, specific cellular neighborhoods of immune cells are now definable with unique abilities to affect cellular phenotypes—and these neighborhoods alter in various cancer disease states. In addition to cancer, these shapes and neighborhoods are altered during immune action and “imprinted” during, and after, pathogen attack, traumatic injury, or auto-immune disease. Hierarchies of functionally defined trans-cellular modules are observed that can be used for mechanistic and clinical insights in cancer and immune therapies.
Please email [email protected] for a link to the seminar.