Seminar - Ivo Spiegel

Dr. Ivo Spiegel is pictured.
December 12, 2022 - 12:00pm
Location: 
601 Fairchild
Ph.D., Department of Brain Sciences

Host: Oliver Hobert

Title: How the genome controls information processing and plasticity in neural circuits

Abstract: The ability to adapt to and learn from novel experiences is essential for an animal’s survival, and key questions in neuroscience concern the underlying molecular, cellular and circuit mechanisms. Genes whose transcription is altered in response to changes in neural activity and to sensory and emotional experiences are required for the development of neurons and synapses and for experience-dependent processes such as memory formation. However, the circuit function of experience-induced transcription and of the underlying genomic mechanisms remain unknown: for example, what are the functions of experience-induced transcriptional networks in regulating information processing in neural circuits? And: do these genetic mechanisms indeed increase the plasticity of neural circuits or rather restrict it? In my talk, I will discuss my lab’s recent experiments in which we focus on the visual cortex of adult mice and combine a wide array of genomic, genetic, electrophysiological, imaging and behavioural approaches to address these fundamental questions in neuroscience.

Business Office

Department of Biological Sciences
500 Fairchild Center
Mail Code 2401
Columbia University
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New York, NY 10027

Academic Office

Department of Biological Sciences
600 Fairchild Center
Mail Code 2402
Columbia University
1212 Amsterdam Avenue
New York, NY 10027
[email protected]
212 854-4581