Seminar - Kaela Singleton

Dr. Kaela Singleton is pictured.
December 7, 2020 - 12:00pm
Location: 
Virtual Seminar - Join Over Zoom
Postdoctoral fellow
Department of Cell Biology
Emory University

Title: Orchestrating Neural Development: Using Systems Biology to define cellular and molecular mechanisms of disease

Abstract: The development of the nervous system involves the specification of neural progenitors and eventual differentiation into mature neurons. Each step in this process is achieved through changes in cell fate and is coordinated by precise expression and function of transcription factors as well as environmental factors such as metals. Dr. Kaela S. Singleton’s research interests are driven by three key questions: How are mature, unique neurons generated and maintained in the brain? How do pathologic mechanisms disrupt molecular and cellular events during neuron generation and development? And why do rare genetic diseases preponderantly affect the nervous system of children? Her graduate research focused on understanding the diverse role of Sox11 a transcription factor critical for neural development in mammalian and non-mammalian models. She identified downstream targets of Sox11 using RNA-sequencing, characterized Sox11-partner protein interactions, and established the domains responsible for Sox11 function both in vivo and in vitro. Her postdoctoral research addresses the molecular and cellular events disrupted in Menkes disease, a progressive form of childhood neurodegeneration that is triggered by dysregulation of copper. She is investigating the role of mitophagy in mitochondrial retention seen in Menkes disease by using mouse and Drosophila models.
 
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