Seminar - Leonard Foster

Dr. Leonard Foster is pictured.
November 7, 2022 - 12:00pm
Location: 
601 Fairchild
Professor and Department Head
Biochemistry & Molecular Biology

Host: Marko Jovanovic

Title: Rearrangement of host protein interactomes in model and non-model systems

Abstract: The ability of proteins to interact to form quaternary and higher-order complexes underlies all of biology. Co-fractionation mass spectrometry (CF-MS) has emerged as a powerful, scalable technique for mapping these interactions. As with any area of science, the methods (both wet-bench and informatic) behind this continue to evolve. There is little consensus on optimal strategies for the design of CF-MS experiments or their analysis. I will discuss our recent efforts to further optimize the whole experimental workflow, from sample preparation to biological interpretation. We then apply these methods to understand how the interactome can respond to different stimuli. I will discuss our efforts to extend these approaches to non-model organisms where a paucity of functional molecular knowledge about the proteins present makes interpretation extremely challenging.

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Department of Biological Sciences
600 Fairchild Center
Mail Code 2402
Columbia University
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New York, NY 10027
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