Department of Biochemistry and Molecular Biology
University of Miami Miller School of Medicine
Host: John Hunt
Title: How Cells Keep Ribonucleases Under Control: Post-translational Regulation of RNase R
Abstract: Ribonuclease are essential in almost every aspect of RNA metabolism, but they are also destructive enzymes that must be kept under control to avoid unwanted RNA destruction. In this seminar I will discuss the growth phase-dependent regulation of the important exoribonuclease, RNase R. This complex process involves components of the trans-translation machinery, post-translational modification, ribosomes and proteolysis. This novel regulatory process is just one of several recently-discovered mechanisms that cells use to control their ribonuclease repertoire.