Seminar - Renata Batista-Brito

photo of Dr. Renata Batista-Brito
January 13, 2020 - 12:00pm
Location: 
601 Fairchild

Dominick P. Purpura Department of Neuroscience

Department of Genetics

Albert Einstein College of Medicine, NY

Host: Maria Tosches

Title: Developmental dysfunction of inhibition alters cortical processing

Abstract: GABAergic interneurons play important roles in cortical circuit development. However, there are multiple populations of interneurons and their respective developmental contributions remain poorly explored.  Neuregulin 1 (NRG1) and its interneuron-specific receptor ERBB4 are critical genes for interneuron maturation.  Using a conditional ErbB4 deletion, we tested the role of vasoactive intestinal peptide (VIP)-expressing interneurons in the postnatal maturation of cortical circuits in vivo.  ErbB4 removal from VIP interneurons during development leads to changes in their activity, along with severe dysregulation of cortical temporal organization and state-dependence.  These alterations emerge during adolescence, and mature animals in which VIP interneurons lack ErbB4 exhibit reduced cortical responses to sensory stimuli and impaired sensory learning.  Our data support a key role for VIP interneurons in cortical circuit development and suggest a possible contribution to pathophysiology in neurodevelopmental disorders. These findings provide a new perspective on the role of GABAergic interneuron diversity in cortical development.

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