Seminar - Stirling Churchman
October 19, 2020 - 12:00pm
Virtual Seminar - Join Over Zoom
Department of Genetics
Title: From the Nucleus to the Mitochondria: Gene Expression Regulation at High Resolution
Abstract: The seminar will discuss our efforts to investigate gene regulatory processes occurring throughout the cell, from the nucleus to the mitochondria. We have recently established co-transcriptional processing (nano-COP) that probes co-transcriptional processing. These approaches monitor where, when and how splicing occurs across long human nascent transcripts that contain multiple introns. We found that splicing occurs in human cells after minutes on average, and interestingly, we observe that proximal introns are more often spliced together than introns spaced apart, indicating that splicing of proximal introns is coordinated. I will also discuss our work towards answering a fundamental question in eukaryotic gene expression: how are nuclear- and mitochondrial-encoded genes co-regulated? We are developing genome-wide approaches to probe how the mitochondrial genome is regulated, from DNA structure to translational control. I will cover our latest work in this area.
Host: Graduate Students
Please email [email protected] for a link to the virtual seminar.
Department of Biological Sciences
500 Fairchild Center
Mail Code 2401
1212 Amsterdam Avenue
New York, NY 10027