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Seminar - Wei Min
November 16, 2020 - 12:00pm
Virtual Seminar - Join Over Zoom
Professor of Chemistry
Department of Chemistry
Title: Chemical Imaging for Biomedicine: the Next Frontier of Light Microscopy
Abstract: Innovations in light microscopy have revolutionized modern biomedical research. Although fluorescence microscopy is currently the method of choice for bio-imaging, it faces several fundamental limitations including the bulky fluorescent tags, limited ability for probing in vivo metabolism, and the “color barrier” for multiplex imaging. In this seminar I will present a novel vibrational imaging technology which is able to address these three challenges all together. First, we devised a Bioorthogonal Chemical Imaging for probing small bio-molecules. This scheme couples the emerging stimulated Raman scattering (SRS) microscopy with tiny vibrational probes. Biomedical applications such as imaging fatty acid metabolism, glucose uptake, drug trafficking, protein synthesis, DNA replication, and tumor metabolism will be presented. Second, we introduced DO-SRS that combines deuterium oxide (D2O) probing with SRS microscopy to image in situ metabolic activities in animals. DO-SRS, being noninvasive and universally applicable, can be adapted to a broad range of systems to study development, aging, and tumor heterogeneity. Third, we invented a super-multiplex optical imaging technique by developing novel spectroscopy and imaging probes. This super-multiplex approach promises to facilitate untangling intricate interactions in complex biological systems.
Host: Rafael Yuste
Department of Biological Sciences
500 Fairchild Center
Mail Code 2401
1212 Amsterdam Avenue
New York, NY 10027