Seminar - Yali Dou

photo of Dr. Yali Dou
October 8, 2018 - 12:00pm
Location: 
601 Fairchild

Professor

Department of Pathology & Biological Chemistry

University of Michigan

Host: Songtao Jia

Title: MLL in development and disease

Abstract: Cell fate decisions are controlled by specific transcription factors acting in concert with chromatin cofactors. Dysregulation of chromatin remodeling enzymes, including MLL family histone methyltransferases, is one of the key characteristics in human malignancies. Our study focuses on how transcription factors, non-coding DNA regulatory regions and chromatin modulating enzymes cooperate to establish and maintain cell fate commitment and how disruption of this process leads to disease development. The mechanistic studies provide critical insights into designing novel target-based therapeutic strategies in cancer treatment and regenerative medicine.

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600 Fairchild Center
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Columbia University
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