Virtual Seminar - Jason Locasale

Dr. Jason Locasale is pictured
November 15, 2021 - 12:00pm
Location: 
Virtual Seminar - Join Over Zoom
Associate Professor
Dept. of Pharmacology and Cancer Biology

Host: Brent Stockwell

Title: Diet and metabolic therapeutics in cancer

Abstract: This presentation will focus on methionine metabolism in health and cancer. I will first discuss methionine content in human food and dietary patterns . I will next focus on how changes to dietary methionine can produced defined consequences on cellular metabolism. I will then discuss work on dietary influences on the activity of the pathway and its relation to the regulation of one carbon metabolism in cancer. How methionine restricted diets may allow for interventions in cancer treatment and relevant mechanisms will be discussed including how changes to dietary methionine can influence interventions that target one carbon metabolism involving radiation and antimetabolite chemotherapies such as 5-fluorouracil. The link between nutritional methionine status and chromatin biology and epigenetics will also be introduced in this talk.

Please email [email protected] for Zoom link to this seminar.

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