Thursday, February 20, 2020 - 11:15
The Tong lab has reconstituted an active human histone pre-mRNA 3'-end processing machinery, consisting of 13 proteins and 2 RNAs, and determined its structure using cryo-electron microscopy.
The structure reveals the overall architecture of the machinery as well as the molecular mechanism for the activation and catalysis of the endonuclease for 3'-end processing:
