Dr. Carol Prives, DaCosta Professor of Biological Sciences at Columbia University, was recently awarded an R35 Outstanding Investigator Award from the National Cancer Institute. The objective of the National Cancer Institute (NCI) Outstanding Investigator Award (OIA) is to provide long-term support (up to seven years) to accomplished investigators with outstanding records of cancer research productivity who propose to conduct exceptional research. It is expected that the OIA would provide extended funding stability and encourage investigators to embark on projects of unusual potential in cancer research.
Dr. Prives was educated in Canada, receiving her BSc and PhD from McGill University. Her postdoctoral training took place at Albert Einstein College of Medicine and the Weizmann Institute, after which she became a faculty member at the Weizmann Institute. She then joined the Biological Sciences Department at Columbia University where she was appointed to a named professorship in 1995. Dr. Prives served as Chair of that department between 2000 and 2004.
Since the late 1980’s her work has focused on the p53 tumor suppressor protein, the product of the most frequently mutated gene in human cancers. She and her group have illuminated aspects of the structure and function of the p53 protein especially as it relates to its roles as a transcriptional activator. In parallel, her group has examined how cancer related mutant forms of p53 regulate tumorigenesis. Work from her laboratory has also illuminated the functions of the p53 negative regulators, Mdm2 and MdmX.
Dr. Prives has published over 240 papers, and serves on the Editorial Boards of several journals including Cell, Genes & Development and PNAS. She has received several honors including being named an American Cancer Society Research Professor, election to the American Academy of Arts and Sciences, the National Academy of Medicine, the National Academy of Sciences and the AACR Academy. She has presented numerous named lectures and has received awards including the NCI Rosalind E Franklin Award for Women in Science, the Paul Jansen Prize in Advanced Biotechnology and Medicine and the AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship and the Ernst Bertner Award from MD Anderson. Dr. Prives has also received an honorary doctorate from McGill University, her alma mater.