Dr. Corinne Abate-Shen's picture
Michael and Stella Chernow Professor of Urologic Sciences and Professor of Pathology and Cell Biology (in the Herbert Irving Comprehensive Cancer Center) and the Institute for Cancer Centers
Herbert Irving Cancer Center, 1130 St. Nicholas Ave.; Room 321B
New York
Office Phone: 
212 851 4731
Short Research Description: 

Computational and preclinical analyses of mouse models of prostate and bladder cancer

Full Research Description: 

Our laboratory has a long-standing interest in understanding the relationship between the processes that control normal development and those that go awry in cancer, with primary interests in prostate and bladder cancer. Over the years, our laboratory has taken a multi-disciplinary approach to investigate mechanisms of cancer initiation and progression using in vivo mouse models. We have generated unique genetically-engineered mouse (GEM) models of prostate and bladder cancer that have provided novel insights into mechanisms of tumorigenesis and valuable pre-clinical models for analysis of new therapeutic approaches and mechanisms of drug resistance. Our GEM models of prostate cancer recapitulate the full spectrum of the disease, ranging from mildly dysplastic to fully metastatic. Similarly, our GEM models of invasive bladder cancer closely mimic the cellular and molecular features of the human disease. In our recent studies, we have been using systems biology approaches for cross-species analyses to integrate experimental data from mouse models and human cancer. Collectively, our studies have led to the development of promising new biomarkers that distinguish cancer subtypes, promising new treatments for intervention, and new ideas about mechanisms of disease resistance.

Business Office

Department of Biological Sciences
500 Fairchild Center
Mail Code 2401
Columbia University
1212 Amsterdam Avenue
New York, NY 10027

Academic Office

Department of Biological Sciences
600 Fairchild Center
Mail Code 2402
Columbia University
1212 Amsterdam Avenue
New York, NY 10027
[email protected]
212 854-4581