Portrait photograph of Victor Cornejo
Postdoctoral Research Scientist
901 Northwest Corner Building, 550 West 120th Street
New York
Office Phone: 
Short Research Description: 

Physiology of synapses

Full Research Description: 

Neurons are structurally complex: most have a single long axon that transmits electrical signals and multiple branching dendrites that receive input from neighboring cells. For many neurons, these dendrites are additionally covered in small dendritic spines that integrate incoming information. Although alterations in the shape or number of dendritic spines are implicated in neurological disorders, little is known about whether these structures have a specialized role in transmitting electrical information independent from their associated dendrite. In the Yuste laboratory, we have developed a method that uses two-photon microscopy and voltage-sensitive fluorescent proteins to measure the electrical activity of dendritic spines in vivo. Combining this approach with state-of-the-art techniques in molecular genetics, neurophysiology, and optogenetics, we are testing whether electrical compartmentalization of spines exists in vivo, and if this is relevant for dendritic computation.

Business Office

Department of Biological Sciences
500 Fairchild Center
Mail Code 2401
Columbia University
1212 Amsterdam Avenue
New York, NY 10027

Academic Office

Department of Biological Sciences
600 Fairchild Center
Mail Code 2402
Columbia University
1212 Amsterdam Avenue
New York, NY 10027
[email protected]
212 854-4581