Development of in vivo selection strategies for evolving proteins with novel catalytic properties
Structure & Biophysics
Single molecule mechanics and engineering.
Cryo-electron microscopy and single-particle reconstruction , studying the mechanism of protein biosynthesis and other molecular processes in the cell.
Mechanistic studies of protein synthesis by the ribosome using single-molecule fluorescence microscopy and other biophysical and biochemical approaches
Molecular mechanisms of DNA recombination and repair; single molecule fluorescence microscopy and other biochemical approaches.
Macromolecular structure; X-ray crystallography
Structural biology of transmembrane transport.
Solid-state NMR studies of enzyme mechanism and membrane protein structure
Biomolecular dynamics, structure, and function; NMR spectroscopy
Imaging and Modeling Biology at Physical Extremes.
Diagramming disease networks with chemical and biological tools.
Structural biology of proteins involved in RNA processing and quality control, and enzymes involved in human diseases (obesity, diabetes, cancer).
Department of Biological Sciences
500 Fairchild Center
Mail Code 2401
1212 Amsterdam Avenue
New York, NY 10027